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Endometrium: definition and meaning

2 min read 路 Updated October 27, 2026

Definition

The endometrium is the inner lining of the uterus. Each menstrual cycle, estrogen makes it thicken and progesterone makes it ready for a fertilized egg to implant. If pregnancy doesn't happen, hormones fall and the top layer sheds as your period. A deeper basal layer stays behind and regrows the lining next cycle.

How it changes in your cycle

PhaseWhat the lining doesTypical thickness
MenstrualTop layer shedsThin, about 2 to 4 mm
Follicular (proliferative)Estrogen rebuilds itGrows to about 5 to 7 mm
Around ovulationLayered, "triple line" on ultrasoundAbout 7 to 11 mm
Luteal (secretory)Progesterone makes it soft and nourishingAbout 7 to 16 mm

Why it matters

  • Period flow: a thicker lining often means a heavier period
  • Fertility: a healthy lining helps an embryo implant
  • Conditions: endometrium-like tissue outside the uterus is endometriosis; inside the muscle wall it's adenomyosis
  • After menopause: a thickened lining or any bleeding should be checked

Without regular ovulation, as with anovulation or PCOS, the lining can keep building under estrogen with no progesterone to balance it. That can cause irregular heavy bleeding and, over years, raises the risk of thickening (hyperplasia), which is why doctors aim for regular bleeds in those conditions. An endometrial biopsy checks the tissue when needed.

When to talk to a doctor

See a doctor about very heavy or prolonged periods, bleeding between periods, periods that come less than every three months for a long time, or any bleeding after menopause.

Frequently asked questions

What is a normal endometrial thickness?

It depends on the cycle phase: thin just after a period and up to about 16 mm in the luteal phase. After menopause it's usually under 4 to 5 mm.

Does the endometrium affect mood?

Not directly. The hormones that shape it, estrogen and progesterone, are the ones linked to mood changes across the cycle.

Sources

  1. Cleveland Clinic: Menstrual Cycle
  2. ACOG: Abnormal Uterine Bleeding FAQ

This page is for information only and isn鈥檛 medical advice. If something worries you, please talk to a doctor.

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