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What is toxic shock syndrome (TSS)?

4 min read 路 Updated October 26, 2026

The short answer

Toxic shock syndrome (TSS) is a rare but life-threatening reaction to toxins made by certain bacteria, usually Staphylococcus aureus or Streptococcus. During periods it's linked mostly to tampons, especially high-absorbency ones left in too long. Symptoms come on fast: high fever, vomiting or diarrhea, dizziness or fainting and a sunburn-like rash. Remove any tampon or cup and get emergency care.

What actually happens in TSS

Some people carry bacteria like Staphylococcus aureus on their skin or in the vagina without any trouble. Under certain conditions those bacteria release toxins into the bloodstream. In a small number of people the immune system overreacts to these toxins, blood pressure drops and organs can start to fail. That's why TSS moves quickly and needs hospital treatment, usually fluids and antibiotics.

TSS isn't only a period problem. It can also follow skin wounds, burns, surgery or childbirth, and it can affect anyone, including men and children. But the link with periods is the one most people hear about, because of tampons.

Symptoms of toxic shock syndrome

The FDA and NHS list these signs. They often look like a bad flu at first, which is why the timing (during or just after your period, with a tampon or cup in) matters so much.

  • A sudden high fever, usually 102掳F (38.9掳C) or higher, or feeling hot, cold and shivery
  • Vomiting or diarrhea
  • Dizziness, or fainting or nearly fainting when you stand up
  • A rash that looks like sunburn, often on the palms and soles
  • Muscle aches, confusion, or skin or lips turning pale, blue or blotchy
  • Peeling skin on the hands and feet, usually a week or two later
This is an emergency

If you have these symptoms during or soon after your period, take out your tampon, cup or disc right away and get urgent medical help: call 911 in the US or 999 in the UK, or go to the emergency room. Tell them you were using a tampon or cup. Don't drive yourself.

How tampons and cups are linked to TSS

Tampons don't contain the bacteria, but a high-absorbency tampon left in for a long time creates conditions where toxins build up more easily. Since super-absorbent materials were removed from the market in the 1980s and labels became standardized, tampon-related TSS has become much rarer. A large review of menstrual cups found only five reported cases of TSS linked to cups, though the true rate can't be calculated.

ProductExact guidance
TamponsChange every 4 to 8 hours. Never wear one for more than 8 hours. Use the lowest absorbency that handles your flow. Use tampons only while you're bleeding.
Menstrual cups and discsEmpty, rinse and reinsert as the manufacturer says (many allow up to 12 hours). Wash hands first and clean or sterilize between periods.
Pads and period underwearNot linked to menstrual TSS. Change when full or every few hours for comfort and hygiene.
The absorbency test

The FDA's rule of thumb: if you can wear one tampon for 8 hours without needing to change it, the absorbency is probably too high. Size down, and use pads or period underwear overnight if you sleep longer than 8 hours.

How to lower your risk

  • Wash your hands before and after inserting a tampon, cup or disc.
  • Pick the lowest absorbency you need, and lower it on lighter days. See how often to change a tampon.
  • Alternate tampons with pads on light days or at night. See how often to change a pad and menstrual cup vs tampon.
  • Don't use tampons for discharge between periods.
  • If you've had TSS before, ask your doctor whether you should avoid tampons and cups entirely.

Knowing when your flow tends to be heavy or light makes this easier. If you track your period, you can plan which product and absorbency to use on which day, instead of guessing. It also helps to know your normal: if your periods are very heavy, that's worth a separate chat with a doctor.

Frequently asked questions

How quickly does TSS develop?

Symptoms usually come on suddenly and get worse within hours. That's why you should seek emergency care instead of waiting to see if it passes.

Can you get TSS from a menstrual cup?

Yes, though it's very rare. A 2019 review found five reported cases linked to cups. Clean hands, a clean cup and emptying it on time keep the risk low.

Is it safe to sleep with a tampon in?

Only if you'll be asleep for less than 8 hours and you put a fresh one in right before bed and change it when you wake. For longer sleeps, a pad or period underwear is safer.

Can you get TSS twice?

Yes. People who have had TSS are more likely to get it again, so doctors often advise avoiding tampons and cups afterwards.

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